Biomedical Engineer Consultant

About the Company

Design Space InPharmatics, the North American division of Product Life Group (PLG), a leading international pharmaceutical consulting organization, is seeking a Bioengineering Consultant to shape our in vivo delivery roadmap and to serve as a critical external expert advising R&D and CMC teams on the design and optimization of strategies for delivering iPSC-derived thymic cells into target tissues. This is a high-impact, scientifically collaborative role at the intersection of biomaterials science, stem cell biology, and translational medicine.

Responsibilities

CELL THERAPY DELIVERY STRATEGY

• Design and evaluate cell delivery approaches (injectable scaffolds, hydrogels, bioengineered constructs) optimized for iPSC-derived thymic epithelial and progenitor cells.
• Advise on routes of administration (subcutaneous, intraperitoneal, intrathoracic, or surgical implantation) tailored to thymic cell engraftment biology.
• Develop criteria for selecting biomaterial matrices and encapsulation systems that support cell viability, immune evasion, and functional thymopoiesis in vivo.

BIOMATERIALS & SCAFFOLD ENGINEERING

• Evaluate natural and synthetic biomaterials (fibrin, collagen, PEG, decellularized ECM, etc.) for compatibility with iPSC-derived cell populations.
• Design or adapt 3D scaffolding or organoid-like constructs that replicate thymic microenvironmental cues and support long-term cell function post-delivery.
• Identify and assess off-the-shelf or custom biomaterial platforms suitable for GMP-compatible scale-up.

PRECLINICAL & TRANSLATIONAL INPUT

• Collaborate with our preclinical team to design in vivo experiments that rigorously test delivery efficacy, cell engraftment, and functional immune reconstitution.
• Advise on animal model selection and surgical/delivery procedures relevant to thymic regeneration studies.
• Provide translational guidance to bridge preclinical findings toward IND-enabling studies and eventual clinical application.

CROSS-FUNCTIONAL COLLABORATION

• Partner with CMC and Analytical Development teams to ensure delivery formulations are compatible with manufacturing and quality requirements.
• Contribute to scientific documentation including protocols, reports, grant deliverables, and regulatory briefing documents.
• Participate in internal scientific meetings, external advisory discussions, and partner interactions as a subject-matter expert.

Qualifications

• Advance degree in Biomedical Engineering, Bioengineering, Materials Science, or a closely related field; MD/PhD or equivalent clinical-research background a plus.
• Demonstrated hands-on expertise in cell therapy delivery, with a track record of translating biomaterial-based delivery systems into in vivo models.
• Practical experience working with iPSC-derived cell types (any lineage) or primary stem/progenitor cell populations.
• Strong command of biomaterials science including hydrogels, decellularized matrices, encapsulation technologies, and scaffold fabrication.
• Knowledge of tissue engineering principles and 3D culture systems relevant to cell therapy applications.
• Familiarity with immune biology sufficient to understand T cell development, thymic function, or immunodeficiency disease contexts.

Required Skills

• Prior experience in thymus biology, thymic organoids, or immune reconstitution models.
• Experience with GMP-compatible biomaterial or delivery platform development.
• Background in immunomodulatory biomaterials or immune-evasive encapsulation strategies.
• Familiarity with IND-enabling study design and regulatory expectations for cell therapy products.
• Experience designing delivery systems for organoid or 3D tissue constructs.
• Existing network in the cell therapy and regenerative medicine space.
• Publications or patents in relevant areas of cell therapy delivery or biomaterials.

Additional Notes

• This is a fully remote, independent consultant role. Consultants are engaged on a project basis and may be assigned to one or multiple concurrent engagements. Hours are not fixed and will fluctuate based on project requirements, milestones, and client needs. Consultants retain full autonomy to accept or decline project engagements at their discretion,

• The responsibilities outlined in this position represent a general summary of the consulting role and are not intended to be all-inclusive. PLG reserves the right to amend this description as client program needs evolve,

• All applications are reviewed by our human hiring team. No automated screening or AI-based filtering is used to evaluate or eliminate candidates. Every candidate receives personal consideration.