National Sales Director

United States | Regular national travel required

Mesoblast is a leader in allogeneic cellular medicines for inflammatory diseases, and our commercial team is committed to ensuring that patients who may benefit from our therapies can access them when it matters most.

We’re looking for a National Sales Director to lead and grow our national sales team, including our Key Account Managers, with a clear focus on reaching appropriate pediatric patients with steroid-refractory acute graft versus host disease (SR-aGvHD). Reporting to our Chief Commercial Officer and working closely with Medical Affairs, Market Access, Patient Services and other cross-functional partners, you’ll set the sales strategy, develop the team and own the results.

You’ll be the bridge between the field and the wider business, connecting teams, sharing what’s happening in the market and keeping our leaders informed as our commercial strategy evolves.

This is a role for someone who thrives when priorities compete. Our environment is ambitious, expectations are high and plans can shift quickly as we grow, so you’ll often need to balance the needs of your team, your customers and the wider business at the same time.

This role can be based remotely anywhere in the US. Regular national travel is required, so proximity to a major airport with strong domestic flight connections is important.

Your impact & responsibilities

• Lead our national sales strategy, translating commercial priorities into clear territory plans, revenue goals and actions.


• Work with Medical Affairs, Market Access and Patient Services to understand and remove barriers at account level, so that appropriate patients who may benefit can access Ryoncil.


• Build senior relationships across transplant centers, hospitals and key clinical and payer stakeholders.


• Own sales performance, forecasting and reporting, using CRM, pipeline data and analytics to turn insights into decisions and action.


• Keep our Executive and Leadership Teams informed on performance, market dynamics, opportunities and risks.


• Bring customer and market insight back into the business to help shape commercial strategy, including pricing, contracting, competitive positioning and go-to-market planning.


• Hire, onboard and develop our Key Account Managers, helping them navigate and succeed in complex accounts.

What you bring to the team

• Significant sales and sales leadership experience in biotechnology, pharmaceuticals or life sciences, typically 10+ years.


• Therapeutic experience in stem cell or bone marrow transplant, hematology/oncology, cell and gene therapy, or rare disease is preferred.


• Established relationships across US transplant centers, academic medical centers and specialty hospital networks.


• Experience leading, coaching and developing high-performing, experienced sales teams across multiple territories.


• A strong record of growing revenue through complex healthcare or life sciences sales cycles.


• Strong executive communication skills, with the ability to translate commercial performance and field insights into clear updates and recommendations.


• Commercial judgment grounded in data, with the confidence to challenge constructively, make tough calls and maintain high standards.


• A degree in life sciences, biotechnology or a related field is valued. An MBA or advanced degree is preferred.

Rewards & benefits

Total rewards. Base salary of US$295,000 to US$325,000, plus an annual incentive opportunity of up to 30% of base salary and eligibility to participate in the company’s share option program, subject to applicable plan terms and eligibility.

Benefits. Medical, dental and vision coverage, life and disability insurance, a 401(k) with company match, subject to plan eligibility, plus four weeks of paid time off.

Flexibility. Remote working, with regular travel to customers and our New York office.

If this sounds like the right next step for you, we'd love to hear from you. Applications close Monday, November 2, 2026.

Mesoblast is an equal opportunity employer. We welcome applications from all qualified candidates and make employment decisions without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, veteran status or any other characteristic protected by law.

Note to agencies: Mesoblast does not accept unsolicited resumes. Any agency engagement must be agreed in advance with our Talent Acquisition team, and no fees will be paid for unsolicited submissions.