Manager / Senior Manager, Business Systems

In this role you will own the day-to-day management and roadmap of Orca Bio's business systems, with a strong focus on AI applications and the OrcaLink Salesforce-based COC/COI platform. You will partner with cross-functional stakeholders to translate needs into scalable solutions and oversee regulated and non-regulated systems for secure, compliant operations. You will lead a small team, manage contracted development partners, and drive AI-enabled automation to reduce manual work. This is a mission-driven, fast-paced opportunity to shape systems that enable life changing therapies at scale.

• pre-IPO equity
• annual bonus
• medical, dental, and vision benefits
• PTO
• 401(k) plan
• life and AD&D insurance and parental leave

• Manage end-to-end lifecycle of business systems requests ( intake, configuration, testing, deployment, post-launch support)
• Evaluate and integrate new systems (CRM, ERP, QMS, MES, CTMS, HRIS) as Orca Bio grows
• Collaborate with stakeholders to translate needs into scalable solutions
• Support OrcaLink configuration, release planning, and roadmap priorities with Salesforce administrators
• Lead IT assessments for OrcaLink focusing on security, access controls, and connectivity
• Identify and drive adoption of AI applications and automation across the business
• Serve as bridge between business and development teams on AI and platform initiatives
• Mentor and grow a small team of business systems analysts/administrators
• Support CSV activities for GxP-regulated systems with Quality and Validation teams
• Maintain documentation, diagrams, and SOPs for owned platforms

• Bachelor's degree in a related field or equivalent experience
• 5-8+ years in business systems, IT applications, or systems administration
• 3-5 years in a regulated life sciences/biotech environment
• Experience implementing and administering enterprise platforms (CRM, ERP, QMS, MES, CTMS)
• Hands-on experience delivering AI applications and translating business needs into requirements
• Working knowledge of GxP, 21 CFR Part 11, and CSV practices
• Experience mentoring or leading cross-functional teams
• Strong data security, access control, and audit-readiness knowledge
• Excellent communication skills for non-technical stakeholders

• cross-functional collaboration
• leadership and mentoring
• effective communication
• Salesforce administration
• AI applications and automation
• CSV and QCCR processes