Xencor is looking for Associate Scientist in Monrovia, CA.
This local job opportunity with ID 42976164 is live since 05/22/2019.
Xencor is an innovative, clinical-stage biotechnology company located in the Los Angeles area (near Pasadena). We are developing engineered monoclonal antibodies for the treatment of cancer, autoimmune diseases, asthma and allergic diseases. We have an excellent opportunity for an Immunologist/Cell Biologist to join our team. Our capabilities and the modular nature of our technology allows us to quickly identify and create new platforms and drug candidates for clinical development. Currently, 12 candidates engineered with Xencor's XmAb® technology are in clinical development internally and with partners (such as Novartis, Amgen and Genentech). Xencor's XmAb antibody engineering technology enables small changes to the structure of monoclonal antibodies resulting in new mechanisms of therapeutic action. The first antibody that incorporates an XmAb technology has been approved for commercial marketing in the United States. Our employees are the most important factor in our success and we have assembled a highly talented group from diverse backgrounds and disciplines to execute our business plan and shape our future. Xencor employees value new ideas and flexibility and demand from each other scientific rigor, a passion for innovation, and a willingness to take risks. We are seeking a PhD scientist to join our cell biology group at the Associate Scientist/Scientist level. Additional postdoctoral and/or industry experience is a plus. The cell biology department plays an important role in discovery projects. It supports screening of therapeutic proteins for biological activity, development of assays to understand mechanism of action, and provides flow cytometry support to in vivo studies. The ideal candidate is highly motivated, able to work in a fast-paced environment, and passionate about developing immunomodulatory therapeutics for the treatment of cancer and autoimmune diseases. She/he will contribute towards identification of therapeutic candidates using cellular and immunological methods. This is an exciting opportunity to impact the next wave of drug development candidates to enter our pipeline. Candidates should have a demonstrated record of technical proficiency and scientific creativity, and an ability to work effectively with other talented scientists. Job Duties include: • Develop and conduct immunological and cellular bioassays to support development of clinical candidates. • Support translational and animal model studies for testing the efficacy and safety of therapeutic proteins. • Document experimental protocols, design and details in an electronic laboratory notebook • Analyze and interpret experimental data, and prepare presentations and technical reports • Communicate data to team members in a timely manner and present data to senior management in departmental and companywide meetings. • Follow all laboratory safety guidelines, practices and protocols. Qualifications: • Minimum of PhD; post-doctoral or industry experience is a plus • Technical expertise in multicolor flow cytometry • Experience in human immunology and designing experiments with human PBMCs • Familiarity with antigen-specific immune responses, cytokine biology and tumor immunology • Extensive experience in culturing of primary cells from mouse or human tissues • Expertise with software such as BD FACSDiva, FlowJo, Prism and Excel for data and statistical analysis Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.